Experimental Study of Chemoprevention by A COX-2 Selective Inhibitor for Mice Colorectal Carcinogenesis.
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Selective COX-2 inhibitor celecoxib prevents experimental autoimmune encephalomyelitis through COX-2-independent pathway.
Cyclooxygenase (COX) is a key enzyme of arachidonic acid metabolism and exists as two distinct isoforms. COX-1 is constitutively expressed in most tissues, whereas COX-2 is inducibly expressed at the site of inflammation. Selective inhibitors of COX-2 have been developed and have been used as anti-inflammatory agents. Here, we show that a new-generation COX-2 inhibitor, celecoxib, inhibited exp...
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ژورنال
عنوان ژورنال: Nippon Daicho Komonbyo Gakkai Zasshi
سال: 2001
ISSN: 1882-9619,0047-1801
DOI: 10.3862/jcoloproctology.54.317